低分子量肝素与纳洛酮合用治疗急性脑梗死临床研究

THE CLINICAL CURATIVE EFFECT OF LOW MOLECULAR WEIGHT HEPARIN AND NALOXONE IN THE ACUTE CEREBRAL INFARCTION

目的 :观察低分子量肝素与纳洛酮合用治疗急性脑梗死的疗效及治疗前后的血液流变学变化。方法 :将 68例急性脑梗死病人随机分为治疗组 3 4例 ,给予低分子量肝素 0 4mL脐周皮下注射 ,每 12h 1次 ,纳洛酮 0 8mg加入 5 %葡萄糖 10 0mL中静脉滴注 ,每天 1次 ,共 10天 ;对照组 3 4例 ,应用复方丹参 2 0mL加入低分子右旋糖酐 5 0 0mL中静脉滴注 ,每天 1次 ,共 10天。治疗前后检测血液流变学指标。结果 :治疗组显效率 71% ,总有效率91% ,均显著高于对照组 (P <0 0 1) ,且能改善血液流变学。结论 :低分子量肝素与纳洛酮合用治疗急性脑梗死安全有效 ,并能降低血液流变学指标。

Objective:To study the curative effect of low molecular weight heparin and naloxone in acute cerebral infarction and the change of hemorrheology.Method:68 cases with cerebral infarction were randomly into two groups.Low molecular weight heparin(LMWH) and naloxone group was injected 0.4 mL LMWH subcutaneously twice a day and 0.8 mg Naloxone with 5% glucose 100 mL in vein injection once a day for 10 days.The routine treatment group was administered once a day with 20 mL compound dancen and 500 mL low molecular dextran in vein injection for 10 days.Examine the change of the indexes of hemorrheology.Results:The LMWH and naloxone group had a obvious effect rate of 71% and a total effect rate of 91%.This group has significant difference from routine treatment group (P<0 01)and could improve the hemorrheology.Conclusion:LMWH and naloxone can be safe and effective for the treatment of the acute cerebral infarction,it also can lower the indexes of hemorrheology.