干扰素联合大剂量胸腺肽治疗慢性乙型病毒性肝炎

Treatment chronic hepatitis B with interferon as well as heave dose of thymopeptide

目的 :探讨干扰素联合大剂量胸腺肽对慢性乙型病毒性肝炎的治疗作用及机制。方法 :按诊断标准选择慢性乙型病毒性肝炎 1 0 0例 ,随机分为干扰素联合大剂量胸腺肽治疗组 (50例 )和干扰素对照组 (50例 ) ,观察比较两组患者的转氨酶及HBeAg、HBVDNA的变化 ,结果 :干扰素联合大剂量胸腺肽治疗组的转氨酶复常率 ,HBeAg及HBVDNA阴转率均明显高于对照组 (P <0 .0 5) ,结论 :大剂量胸腺肽能促进HBeAg的阴转 ,抑制HBV的复制 ,提高细胞免疫应答能力 ;干扰素联合大剂量胸腺肽治疗慢性乙型病毒性肝炎有较好的疗效 。

Objective To study interferon combined with heave dose of thymopeptide effects on chronic hepatitis B.Methods 100 cases with chronic hepatitis B were chosen according to diagnostic standard of chronic hepatitis B. These cases were divided into two groups randomly (grorp of interferon combined with thymopeptide and control grorp of interferon ).We observed the change of alanine-amino-transferase(ALT) and aspartate-amino-transferase(AST) and HBeAg and HBV-DNA.Results The effects of the treatment group were better than the control group in normal rates of ALT and AST and negative rates of HBeAg and HBV-DNA,and there were significant differences compared with two groups(P<0.05).Conclusion Heave dose of thymopeptide can improve the negative rate of HBeAg and inhibit copying of HBV-DNA, and increase the cell immune function of chronic hepatitis B. Heave dose of thymopeptide combined with interferon had better effects on chronic hepatitis B, with good safety.