巨核细胞成熟障碍临床分析

Clinical analysis of megakaryocyte mature hindrance

目的 探讨巨核细胞成熟障碍患者巨核细胞、血小板 4项参数改变及其临床意义。方法 对2 8例巨核细胞成熟障碍患者根据疾病性质分为 ITP、其它血液病、非血液病组 ,并设正常对照。检测骨髓巨核细胞及外周血血小板 4项参数。结果 本组 2 8例均有明显成熟产板巨核细胞和血小板减少 ,与正常对照组相比有显著性差异 ( P <0 .0 1 )。ITP组与其它任一组相比每单位面积巨核细胞数明显增加 ( P <0 .0 1 )。血小板压积 ( PCT)、平均血小板体积 ( MPV)、血小板分布宽度 ( PDW)变化具有统计学意义 ( P <0 .0 1 ) ,而其它血液病、非血液病组与对照组比较无显著性差异。结论 巨核细胞成熟障碍见于多种疾病 ,骨髓巨核细胞数明显增加和血小板 4项参数改变是 ITP的重要特征 ,有助于临床鉴别诊断。

Objective To investigate the clinical significance and changes of the megakaryocyte and 4 indexes blood platelet parameters of patients with megakaryocyte mature hindrance.Methods 28 cases with megakaryocyte mature hindrance were divided into 3 groups in terms of illness types:idiopathic thrombocytopenic purpura(ITP)?other hemayonosis and other disease group,10 cases without detectable diseases as controls.The megakaryocytes were assayed under microscopyby,and the blood platelet parameters were determined by blood autoanalyzer.Results There were markedly decrease of mature megakaryocyte and platelet in all groups.The numbers of megakaryocytes in ITP group was higher than that in other any group,and there were significantly diference in PCT?MPV and PDW between ITP group and other any group.Conclusions There is megakaryocyte mature hindrance in a several of diseases.The increases of numbers of megakaryocytes in marrow and changes of parameters in blood is a main speciality in ITP.It is important to differential diagnosis in clinic.