七宝美髯丹对衰老大鼠自由基及免疫指标的影响

Effects of Qibao Meiran Pellet on Free Radicals and Immune Indexes in Aging Rats

[目的]通过动物实验观察补益肝肾古方七宝美髯丹及其配伍益气健脾药、补肾药、活血通下药延缓衰老的作用机理。[方法]10月龄大鼠以D—半乳糖造模,观察七宝美髯丹及其与各配伍中药对自由基及免疫指标的影响。[结果]七宝美髯丹能明显提高血中超氧化物歧化酶(SOD)活性;七宝美髯丹配伍补肾药或活血通下药在降低血中丙二醛(MDA)值的同时,还分别能提高谷胱甘肽过氧化物酶(GSH—Px)活力及SOD活性。七宝关髯丹配伍补肾药还能明显提高白细胞介素2(IL—2)活性。[结论]补益肝肾中药有延缓衰老的作用;益气健脾和活血通下药在延缓衰老方面也有不可忽视的作用。结果还提示,中药延缓衰老作用与性别因素有关。

[Objective] To observe the anti - aging effects and explore the mechanism of Qibao Meiran Pellet (QMP) and its modified prescriptions, including QMP with qi - invigorating and spleen - strengthening herbs, with kidney -nourishing herbs or with blood - activating and purgative herbs. [ Methods ] Ten - month - old model rats were established by D - galactose. Serum free radical levels and immune indexes in QMP group and various modified QMP groups were observed. [ Results ] QMP increased the activity of superoxide dismutase ( SOD). QMP combined with kidney - nourishing herbs or blood - activating and purgative herbs decreased the serum level of malondialdehyde (MDA) and increased the activities of glutathione peroxidase (GSH - Px) and SOD. Meanwhile, QMP combined with kidney -nourishing herbs increased interleukin - 2 activities. [ ConclusionJ QMP, mainly composed of herbs for nourishing liver and spleen, can delay the aging of rats, and spleen - strengthening herbs and blood - activating and purgative herbs also play an important role in the delay of aging. Furthermore, it is suggested that the anti - aging effect of herbal medicine is related to the sex.