灵芝煎剂治疗鹅膏毒蕈中毒的临床研究

A Clinical Study on the Therapeutic Effect of Lingzhi Decoction on the Poisoning Patients by Amanita Mushroom

目的探讨灵芝煎剂对鹅膏蕈中毒病人的治疗作用。方法将鹅膏蕈中毒病人 2 3例随机分为治疗组和对照组。对照组给予常规治疗 (青霉素、阿拓莫兰 ) ,治疗组在常规治疗基础上 ,加用灵芝煎剂口服 ,比较两组的临床疗效及内脏损害情况。结果治疗组临床疗效明显优于对照组 (P <0 .0 1 ) ;两组总胆红素(STB)、胆汁酸 (BA)、谷丙转氨酶 (ALT)、谷草转氨酶 (AST) 4项指标均上升。治疗组在第 3d 4项指标上升达高峰 ,以后逐渐下降 ,差异有非常显著性 (P <0 .0 1 ) ;对照组 4项指标则呈持续进行性上升 ,差异有非常显著性 (P <0 .0 1 ) ;两组 4项指标在相同时间比较 ,治疗组明显低于对照组 ,差异有非常显著性 (P <0 .0 1 )。结论灵芝煎剂对鹅膏蕈中毒有较好的治疗作用 。

?Objective To observe the therapeutic effect of Lingzhi Decoction(LD) on the patients with amanita mushroom poisoning.Methods 23 cases with amanita mushroom poisoning were randomly divided into controlling group (11 cases) treated by conventional therapy (penicillin, reduced glutathione) and treating grop (12 cases) treated by LD combined with conventional therapy (LD 200?ml,po,tid).Results The therapeutic effect in treating group was significantly superior to that in controling group (P<0.01).The levels of total serum bilirubin (STB),bile acid (BA),alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were all obviously increased in the two groups of patients with amanita mushroom poisoning, getting to the peak value at the third day among cases in the second group. Then, they were significantly reduced in the treating group (P< 0.01 ). In contrast, these indexes increased consistantly in controlling group with significant difference (P<0.01). The total levels of STB,BA,ALT and AST were obviously lower in treating group than in controlling one. Conclusions Lingzhi Decoction is very effective in the treatment of patients with amanita mushroom poisoning and can remarkably decrease the mortality of this lesion. 〔