低钙饮食对雌雄大鼠股骨生物力学特性的影响

EFFECTS OF LOW CALCIUM DIET ON THE BIOMECHANICAL PROPERTIES OF MALE AND FEMALE RATS FEMUR

目的 评价低钙饮食对雌雄大鼠股骨生物力学性能的影响,并比较雌雄大鼠间的差异。方法 3月龄SD雌雄大鼠各30只,按性别随机分成对照组(Ca1.0％)、极低钙组(VLCD)(Ca 0.1％)、低钙组(LCD)(Ca 0.3％)。三月后处死大鼠,取左侧股骨,行股骨三点弯曲实验。结果 VLCD和LCD组雌性大鼠各生物力学指标与对照组相比无显著性差异。雄性大鼠LCD组与对照组差异无显著性,而VLCD组生物力学指标如极限载荷、极限强度、破坏时能量吸收以及刚度系数均较对照组显著降低。结论 低钙饮食对雄性大鼠骨生物力学的影响较雌性为甚,这可能是雄性大鼠增重较快所致。

Objective To evaluate the biomechanical effects of low calcium diet on male and female rat femur and compare the biomechanical difference between male and female rat. Methods Sixty 3 -month - old Sprague - Dawley male and female rats were randomized into three groups: control group , very low calcium diet group (VLCD) and low calcium diet group (LCD) . After 90 days, all rats were killed. The left femur from each rat was obtained for three - point bending test. Results Comparing with control group, VLCD and LCD group had no significant difference in biomechanical properties in female rats. Biomechanical properties in male rats also had no significant differences between LCD and control group, but male rats of VLCD had significantly lower maximum load, energy absorption and stiffness than those of control group. Conclusion The results indicated biomechanical properties in male rats were reduced more than those in female rats with the effect of low calcium diet, which body weight may play an important role.