补肾化瘀解毒法对ITP患者血浆蛋白C和P-选择素的影响 附:60例病例报告

Influence of Invigorating the Kidney and Eliminating Blood Stasis and Detoxifying Therapeutics by TCM on Plasma Protein C & P-Selectin for Idiopathic Thrombocyt openlc Purpura Patients--Attachment 60 Cases Report

目的：观察补肾化瘀解毒中药对慢性特发性血小板减少性紫癜（ITP）和P－选择素影响，进而探讨中药疗效的作用机理，为临床用药提供依据。方法：将60例ITP患者随机分为2组，分别给予补肾化瘀解毒中药和泼尼松治疗，通过临床观察和对血浆蛋白C和P－选择素治疗前后的检测结果，分析补肾化瘀解毒中药对前述两项指标的影响。结果：两组患者治疗前后其血小板计数，均较治疗前有所增加（P＜0．05），但两组间对照其差异无统计学意义（P＞0．05）。两组治疗前后，其血浆蛋白C均有增高（P＜0．01），P－选择素则有所降低（P＜0．01）。结论：补肾化瘀解毒中药对ITP患者有较好疗效，其疗效与泼尼松相近，但却没有泼尼松之类激素的毒副作用。其治疗机理可能与有效有效调节的血浆蛋白C和P－选择素含量有关。

Objective: Studying the influence of invigorating the kidney and eliminating blood stasis and detoxifying therapeutics by TCM (IKESDT) on plasma protein C & P- Selectin for chronic idiopathic thrombocytopenlc purpura (ITP) patients, searching for its curative principle to provide clinic base. Method: Randomly dividing 60 ITP cases into two groups and treated with IKESDT herbs and prednisone respectively, detecting plasma protein C & P- Selectin before and after treatment. Result: Platelet count increases for two groups respectively after treatment (P<0.05), but there is no statistical difference between two groups(P>0.05). Plasma protein C increases for two groups respectively after treatment (P<0.01) while P- Selectin decreases (P<0.01). Conclusion: IKESDT herb has similar curative effect on ITP as prednisone, but without hormone-like side effect in prednisone. This effect may relate to its function to adjust plasma protein C & P- Selectin content.