苦参碱滴眼液对家兔实验性眼炎的药效学研究

Pharmacodynamic Studies on Matrine Eye Drops for Experimental Ocular Inflammation in Rabbits

目的 观察苦参碱滴眼液对家兔实验性眼炎的治疗作用。方法 将0.5％、1.0％苦参碱滴眼液、地塞米松磷酸钠滴眼液和生理盐水溶液分别滴入兔眼结膜囊内,观察药物对兔眼前房穿刺引起房水蛋白浓度升高和辣椒酊刺激引起眼炎模型的抑制作用。结果苦参碱滴眼液能有效地抑制兔眼前房穿刺引起的房水蛋白浓度升高,且对辣椒酊刺激引起的兔外眼部、前眼部炎症反应与地塞米松磷酸钠滴眼液疗效相当。结论苦参碱滴眼液对家兔实验性眼炎有较好的治疗作用。

Objective To investigate the therapeutic effects of matrine eye drops (MED) on experimental ocular inflammation in rabbits. Methods The effects of 0. 5 % and 1.0% MED, dexamethasone eye drops, saline solution were e-valuated in the rabbits with ocular inflammation induced by paracentesis of anterior chamber and capsicum tincture respectively. Results MED could significantly inhibited the increase of protein concentration in aqueous humor induced by anterior chamber paracentesis, and the anti - inflammatory effect of MED on capsicum - tincture - induced extra ocular and intraocular inflammation was similar to dexamethasone eye drops. There were no significant difference between 1.0% MED and dexamethasone eye drops. Conclusion MED has a good effect on experimental ocular inflammation in rabbits.