鼻咽癌中P_(16),C—myc和PCNA的表达

The Experssions of P_(16) C-myc and PCNA inthe Nasopharyngeal Cancer Tissue

目的 :探讨鼻咽癌组织中P16,基因myc(C—myc)和增殖细胞核抗原 (PCNA)表达异常的意义。方法 :采用免疫组织化学 (S—P)方法。结果 :4 7例鼻咽癌组织中P16阳性 13例 (13 4 7) 2 8 5 % ,C—myc阳性38例 (38 4 7) 81% ,PCNA阳性 4 7例 (47 4 7) 10 0 %。结论 :P16的低表达 ,C—myc和PCNA的过表达在鼻咽癌细胞增殖和癌变过程中起重要作用。

Objective:To study the meaning of expressions of P 16 ,C-myc and PCNA in the nasopharyngeal cancer tissue.Methods:By using s-p immunohistochemical methods.Results:The positive expressions for P 16 were 28%,C-myc were 81% PCNA were 100% in the nasopharyngeal cancer tissue.Conclusions:The results show that P 16 low expression and C-myc,PCNA over expression may play a important role in cell proliferation and canceration of nasopharyngeal cancer.