急性缺血性脑血管病患者血清sICAM-1和sVCAM-1动态变化及临床意义

The dynamical changes and clinical significances of the serum soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 levels in the patients with acute ischemic cerebrovascular diseases

目的 :探讨脑缺血患者血清可溶性细胞间粘附分子 1(sICAM 1)和可溶性血管细胞间粘附分子 1(sVCAM 1)水平的动态变化规律及其意义。方法 :应用ELISA法分别检测脑缺血后第 1、2、5天患者血清中sICAM 1、sVCAM 1水平 ,同时测定第 2天血糖水平。结果 :发病后 2 4小时内患者血清中sICAM 1、sVCAM 1水平即开始升高 ,分别为 2 6 6 .2 8± 6 2 .16ng/ml、6 87.19±356 .76ng/ml;第 2天明显升高 2 85.77± 6 8.4 3ng/ml、990 .79± 36 8.36ng/ml;第 5天又有所下降 ,分别为 2 6 3.6 0± 87.82ng/ml、977.70± 384 .16ng/ml,但仍高于对照组。发病后第 2天血糖水平与sICAM 1水平升高呈线性正相关。结论 :脑缺血患者血清sICAM 1、sVCAM 1水平均升高 ,表明ICAM 1和VCAM

Objective:To explore the dynamical change regularities and significances of the serum soluble intercellular adhesion molecule 1 (sICAM 1) and soluble vascular cell adhesion molecule 1(sVCAM 1) levels of the patients with acute cerebral ischemic attack. Methods:The sICAM 1 and sVCAM 1 were measured using ELISA at the 1st day,2nd day and 5th day after onset, respectively. At the same time,the blood glucose was measured at the 2nd day. Results:The serum sICAM 1 and sVCAM 1 concentrations increased within 24 hours after onset (266.28 ± 62.16ng/ml 、687.19 ± 356.76ng/ml) ; They increased obviously in the 2nd day (285.77±68.43ng/ml、990.79±368.36ng/ml) and declined gradually in the 5th day (263.60±87.82ng/ml、977.70±384.16ng/ml). But they were still higher than that in Control group. The changes of the concentrations of the blood glucose and sICAM 1 in the 2nd day after onset indicated that both of them were of positive linear correlation. Conclusion:The increase of the serum sICAM 1 and sVCAM 1 concerntrations of the patients with cerebral ischemia demonstrated ICAM 1 and VCAM 1 may involve in the processes of cerebral isehemic injury.