川芎嗪对早期糖尿病肾病的治疗作用

EFFECTS OF LIGUSTRAZINE ON EARLY DIABETIC NEPHROPATHY

①目的 观察川芎嗪对早期糖尿病肾病 (DN)的治疗作用。②方法 早期DN病人 62例随机分为川芎嗪治疗组和对照组 ,对照组行饮食控制及应用胰岛素或糖适平控制血糖 ,治疗组在上述治疗基础上加川芎嗪治疗 ,共 4周。观察两组治疗前后血糖、血常规、血生化、肝功能、肾小球滤过率 (GFR)、尿清蛋白排泄率 (UAER)、血和尿 β2 微球蛋白 ( β2 MG)的变化及治疗过程中出现的副作用。③结果 治疗后两组病人血糖、GFR、UAER、血和尿 β2 MG与治疗前比较明显改善 (t=2 .917～ 5 .12 6,P <0 .0 5 ) ,而治疗组GFR、UAER、血 β2 MG改善优于对照组(t=2 .10 5～ 2 .864 ,P <0 .0 5 )。川芎嗪治疗过程中对病人无明显的副作用。④结论 川芎嗪对早期糖尿病肾病病人有明显疗效 。

Objective To observe the effects of Ligustrazine on early diabetic nephropathy(DN). Methods Sixty-two patients with early DN were randomly divided into control group (31 cases ,regular therapy) and treated group (31 cases ,regular therapy plus Ligustrazine). The course of treatment was 4 weeks. The glomerular filtration rate (GFR),urinary albumin excretion rate(UAER),blood and urine β 2-microglobulin(β 2-MG) were determined for both groups before and after the treatment, the side effects during the treatment were observed as well. Results Blood sugar, GFR, UAER, blood and urine β 2-MG were improved very much for the both groups after the treatment (t=2.917-5.126, P<0.05), but the treated group was much better than that of the control group in terms of GFR, UAER and blood β 2-MG (t=2.105-2.864, P<0.05). No obvious side effects were found by using Ligustrazine during the treatment. Conclusion Ligustrazine has a beneficial effect on early diabetic nephropathy.