摘要
应用寿命表法对129例卵巢恶性肿瘤手术病人计算5年累积生存率,并采用Cox模型对其中资料完整的102例病人23项指标进行多因素分析,从中筛选出对生存时间影响显著的8个因素,按它们对生存时间的作用大小依次排列为:临床分期、手术方式、发生于非特异性间质的恶性肿瘤、转移性癌、化疗、血红蛋白含量、民族和一般情况.其中,临床分期为晚期、病理系非特异性间质的恶性肿瘤和转移性癌、入院时一般情况差是危险因子,可缩短生存时间;而采用根治术、化疗尤其是联合化疗、手术前血红蛋白含量高和少数民族为保护因子,能延长生存时间.根据Cox模型的预后指数(PV)对93例病人的预后进行预测,并与5年随访实际结果比较,符合率和灵敏度分别为87.10%、88.89%,预测结果与实际结果基本相符.
129 operated patients with ovarian malignancies were analysed by the life table tech-nique to obtain a 5 year cumulative survival rate.Using the Cox regression model, a multivariate statisti-cal analysis was made in 102 patients in order to find out the most important prognostic factors.Among the 23 suspicious influencing factors, only 8 factors showed a significant relationship with prognosis.Clin-ical staging was the most important factor which influenced the postoperative survival time.The mode of the operation played the second important role.The predicting value (PV) was calculated according to the individual featuers of 93 patients which could be used for evaluating the prognosis.It's reliability and sensitivity were 87.10% and 88.89%, respectively.
关键词
卵肿瘤
预后因素
ovarian malignancies
Cox model
prognostic factor
