摘要
①目的 探讨端粒酶作为肺癌诊断标记物的可行性及临床意义。②方法 用TRAP法检测 2 9例肺癌组织、2 7例癌旁组织和 35例正常组织标本中端粒酶活性表达。③结果 2 9例肺癌组织中 2 1例 (72 .4 % )端粒酶活性表达阳性 ,2 7例癌旁组织中 6例 (2 2 .2 % )端粒酶活性表达阳性 ,35例正常组织均不表达端粒酶活性。癌组织、癌旁组织与正常组织标本端粒酶活性比较有显著差异 (χ2 =34.0 13、3.937,P <0 .0 1、0 .0 5 )。④结论 端粒酶表达与肿瘤发生有关 ,其癌旁组织中端粒酶活性有可能成为判定肿瘤复发和预后的指标。
Objective To study the feasibility and clinical significance of telomerase as a marker in the diagnosis of lung carcinoma.\ Methods\ The expression of telomerase activity was detected in samples of 29 human lung carcinomas , 27 adjacent tissues and 35 normal ones by TRAP. \ Results\ In the 29 lung carcinomas studied, telomerase activity was detected in 21 cases(72.4%). 6(22.2% ) of adjacent tissues showed positive telomerase. 35 normal tissue showed negative. The difference was significant between them ( χ 2=34.013, 3.937, P <0.01, 0.05).\ Conclusion\ The occurrence of tumors is related to telomerase expression. The telomerase activity may become a marker to determine the recurrence and prognosis of the disease.
出处
《青岛大学医学院学报》
CAS
2003年第1期51-52,共2页
Acta Academiae Medicinae Qingdao Universitatis
