肝细胞异型增生的产生及其与肝细胞癌发生关系的实验研究

AN EXPERIMENTAL STUDY ON THE RELATIONSHIP BETWEEN LIVER CELL DYSPLASIA AND PRIMARY HEPATOCELLULAR CARCINOMA DEVELOPMENT IN TREE SHREWS

82只实验树鼩分为四组:A组26只,感染了HBV并同时给予AFB_1;B组34只,未感染HBV但给予AFB_1;C组13只,只感染了HBV;D组9只,既未感染HBV,又未接触AFB_1.实验158周.A组发生LCD16例(61.53%),其中9例发生HCC(56.25%).B组出现LCD18例(52.94%),其中3例发生HCC(16.66%).C组出现LCD 6例(46.15%);D组无LCD产生.82只树鼩有40只出现LCD,其中12只发生HCC(30%).而无LCD的42只,只有1例(C组)产生HCC(2.38%).LCD阳性组发生HCC的相对危险性为LCD阴性组的12.6倍.感染了HBV的树鼩,其LCD发生率显著高于未感染者(P<0.05);而在未感染HBV的动物中,摄入AFB_1的,其LCD发生率也同样比未摄入者高(P<0.05).表明HBV和AFB_1都能诱发LCD;LCD是HCC的癌前病变.

82 experimental tree shrews were divided into four groups in which there were 26,34,13,and 9 tree shrews in group A,B,C and D respectively.Group A was positive for HBV markers and was fed with aflatoxin B_1(AFB^1);Group B was negative for HBV markers and was also fed with AFB_1.Group C was infected with HBV only, and D was uninfected.In group A 16 cases (61.53%) developed liver cell dysplasia (LCD) ,and hepatocellular carcinoma (HCC)were detected in nine among these 16 cases (56.25%).In group B 18 cases(52.94%)developed LCD ,and among them there were only three cases of HCC.Six LCD appeared in group C and none in group D.Among 40 tree shrews which were positive for LCD, twelve developed HCC.But, only one HCC developed in those 42 animals which were negative for LCD.LCD incident rate is significantly higher in the infected tree shrews than those uninfected.On the other hand, the incident rate of LCD in the tree shrews exposed to AFB_1 is significantly higher than those groups which were not exposed to AFB_1.These results indicated that:LCD may be induced by HBV and AFB_1 ,and perhaps may be the precarcinoma changes of HCC.