PTEN和nm23-H_1蛋白在乳腺癌组织中的表达及其临床意义

Expression of proteins of PTEN,and nm23-H_1 in breast carcinoma and their clinical significance

目的 :研究 10号染色体缺失且与张力蛋白同源物磷酸脂酶 (PTEN)、nm2 3 H1蛋白在乳腺癌组织中的表达并探讨其临床病理意义。方法 :应用S P免疫组织化学法检测 70例乳腺癌组织中PTEN、nm2 3 H1蛋白表达水平。结果 :乳腺增生性病变和良性肿瘤组织中PTEN呈高表达 ;远处转移组PTEN高表达率低于无转移组 ,两组间差异有显著意义 (P <0 0 5 )。PTEN表达水平与患者年龄、肿瘤最大直径、淋巴结转移、组织学分级及类型无关 ,但在低年龄组和淋巴结转移组PTEN低表达率增高 ,有相关趋势。nm2 3 H1低表达者易发生转移复发 (P <0 0 5 )。结论 :同时检测PTEN、nm2 3 H1的蛋白表达对预测乳腺癌患者的复发和转移具有指导意义 。

Objective To study the expressions of PTEN and nm23?H 1 in breast carcinoma and their clinical significance.Method The expressions of those proteins was explored by immunohistochemistry S?P in 70 cases of breast carcinoma.Results High expression of PTEN was found in all proliferative lesions and benign tumor tissues.In distant metastasis group, high expression rate of PTEN has markedly declined(P<0.05).Expression of PTEN was not related to age,the maximum size of tumor histological grade and type and axillary lymph node metastasis.However,low PTEN expression has risen in lymph node metastasis group and that less than 45 years.Low level of expression of nm23?H 1 protein was significantly associated with lymphatic metastasis and recurrence.Conclusion Combined examination of PTEN and nm23?H 1 expression may be of significant clinical importance in the evaluation of the tendency of recurrence and metastasis.Patients whose PTEN and nm23?H 1 expression are low are liable to recuurence and metastasis.