抗精子抗体对不育症及自然流产的影响

Research on the Relation of Antisperm Antibody to Infertility and Spontaneous Abortion

本文应用试管—玻片凝集试验对480对不育夫妇和178对自然流产夫妇进行血清和/或精浆抗精子抗体(ASAb)测定。不育组ASAb总阳性率为23.12％,其中女方血清ASAb阳性率为14.6％,高于正常对照组(P<0.01):男方血清ASAb阳性率为12.6％,精浆ASAb阳性率为0.9％,后者低于前者(P<0.01)。自然流产组ASAb总阳性率为15.17％,其中女方血清ASAb阳性率为9.0％,亦高于正常对照组(P<0.01);男方血清ASAb阳性率为8.3％,精浆ASAb阳性率为3％。研究结果提示,ASAb是导致不育症及自然流产的重要原因之一,应引起临床医生的高度重视。

480 infertility couples and 178 couples with spontaneous abortions were tested for serum and/or seminal plasma antisperm antibody (ASAb) by tube-slide agglutination test. It was found that the total positive rate of infertility group was 23.120％. In this group, positive female serum was 14.6％, significantly higher than that of the normal control women; positive male serum was 12.6％, while seminal plasma was 0.9％, the latter was significantly lower than the former. The total positive rate in spontaneous abortion group was 15.17％. In this group, the positive rate of female serum was 9.0％, significantly higher than that of the control group. The positive rate of male partners was 8.3％ in serum and 3.0％ in seminal plasma. It is suggested that ASAb is an important factor inducing infertility and spontaneous abortions. There fore, special attention should be paid to ASAb in clinical work.