具有α-葡糖苷酶抑制作用的抗糖尿病药物

Antidiabetic drugs with α-glucosidase inhibition activities

α -葡糖苷酶抑制剂是一类具有糖结构的新型抗糖尿病药物 ,已经被广泛用于临床 ,包括阿卡波糖、伏格列波糖和米格列醇。这类药物可以明显降低Ⅱ型糖尿病人餐后血糖水平 ,减少糖尿病并发症的发生。本文简要综述了这类药物的发现、制备和作用机制及药效学、药动学和临床疗效等。

glucosidase inhibitor is a new kind of antidiabetic drug with carbohydrate stucture including acarbose, voglibose and miglitol widely used to treat type Ⅱ diabetes mellitus in clinic. It can significantly reduce postprandial peak plasma glucose levels, and thus prevents the complications in patients with type Ⅱ diabetes mellitus. This paper briefly reviews some information about their findings, preparations, action mechanisms, pharmacodynamics, pharmacokinetics and clinical efficacy.