急性胰腺炎血清免疫抑制酸性蛋白检测的临床意义

Serum Immunosuppressive Acidic Protein in Patients with Acute Pancreatits

目的 :了解急性胰腺炎患者血清免疫抑制酸性蛋白 (IAP)的临床意义。方法 :应用免疫扩散法检测 32例患者和 2 0例健康人中的IAP水平。结果 :正常组 (2 0例 )、轻症组 (2 0例 )和重症组 (12例 )的血清IAP在入院时分别为(32 5± 10 5 )mg/L、(40 4± 15 1)mg/L和 (5 75± 14 5 )mg/L ,重症组血清IAP水平高于正常组 (P <0 .0 1) ,也高于轻症组 (P <0 .0 5 )。其次重症组IAP值在入院后第 3、5、7天与轻症组比较仍明显升高 ,两组有统计上的差异性。结论

Objective:To evaluate the significance of serum immunosuppressive acidic protein (IAP) in patients with acute pancreatitis.Methods:Thirty-two patients with acute pancreatitis and twenty normal controls were recruited into the study. The serum IAP levels were determined by immunodiffusion. Results:The serum IAP levels in normal controls, mild, severe pancreatitis were (325±105)mg/L?(404±151)mg/L and (575±145)mg/L respectively at admission. The levels of IAP in severe pancreatitis was higher than those in nomal controls(P<0.01) and mild pancreatits (P<0.05). The levels of IAP in severe pancreatitis was significantly higher than those in mild pancreatitis at 3d,5d and 7d, there were significant differences between the two groups.Conclusions:Detecting IAP level of acute pancreatitis may be index for monitoring the severity of pancreatitis.