无症状性多发腔隙性脑梗死事件相关电位与认知的相关性

Event-related potentials in patients of silent multiple lacunar cerebral infarction

目的:探讨事件相关电位(ERP)对无症状性多发腔隙性脑梗死患者认知功能障碍的诊断价值。方法:检测16例无症状性多发腔隙性脑梗死患者的事件相关电位并与正常对照组进行比较。结果:无症状性多发腔隙性脑梗死组ERP的N1,P2,N2,P3潜伏期和P3波幅分别为(83±15)、(155±18)、(242±37)、(359±33)ms和(7±3)μV。与正常对照组比较,两组ERP的N2、P3潜伏期间有显著性差异(P<0.01),而N1、P2潜伏期及P3波幅间无显著性差异(P>0.05)。结论:无症状性多发腔隙性脑梗死患者可伴有认知功能的损害,事件相关电位检测为无症状性多发腔隙性脑梗死患者的认知功能障碍的评定提供了一种敏感、客观的检查手段。

AIM:To investigate the diagnostic value of event related potentials (ERP) for cognitive impairment of patients with silent multiple lacunar cerebral infarction.METHODS:An auditory discrimination paradigm was employed to elicit event related potentials in 16 patients of silent multiple lacunar cerebral infarction as compared with age matched healthy controls. RESULTS:The latencies of N1,P2,N2,P3 and P3 amplitude in the patients of silent multiple lacunar cerebral infarction were (83±15),(155±18),(242±37),(359±33) ms and (7±3)μV respectively. The results indicated that the latencies of N2,P3 in the patients of silent multiple lacunar cerebral infarction were significantly prolonged (P< 0.01) ,whereas the latencies of N1 ,P2 and P3 amplitude showed no significant difference (P >0.05) as compared with age matched healthy controls.CONCLUSION:Patients of silent multiple lacunar cerebral infarction have disorders of cognitive function, and that event related potential test provides a sensitive and objective means of quantifying the level of cognitive impairment for the patients with silent multiple lacunar cerebral infarction.