摘要
目的:研究诱导型一氧化氮合酶(induciblenitricoxidesynthase,iNOS)在人胃癌组织中的表达及其与胃癌微血管形成的关系,以及和淋巴结转移的关系.方法:采用免疫组化SP法检测50例原发性胃癌中iNOS的表达,同时检测微血管密度(microvesseldensity,MVD,以抗CD34标记).结果:iNOS阳性表达率为70%,在淋巴结阴性组和阳性组分别为54.2%和84.6%,两组间的差异有统计学意义(P<0.01);在iNOS阴性表达组MVD均值为11.8±5.9,在iNOS阳性表达(+)、(++)、(+++)组中MVD均值分别为18.7±6.3,24.5±5.6,30.1±9.4,iNOS阴性组和阳性组MVD均值差异有显著统计学意义(P<0.01).结论:iNOS在胃癌组织中有高表达(70%),与癌瘤微血管形成,淋巴结转移有关系.
AIM:To investigate the expression of inducible NOS (iNOS) in human gastric cancer and its relationship with the angio- genesis in gastric cancer and lymphocyte metastasis. METHODS:The expression of iNOS in 50 patients with gas- tric cancer was studied by immunohistochemical SP method with anti-iNOS. Microvessel density (MVD) of human gastric cancer was also determined with anti-CD34 as the labels. RESULTS:The expression rate of iNOS in 50 cases was 70 %, and the rates of node negative and node positive in gastric cancer were 54.2 % and 84.6 %,respectively, with signifi- cant difference (P <0.01). There was a significant differ- ence of MVD (P <0.01) among groups with different ex- pression of iNOS. CONCLUSION:The expression rate of iNOS in human gastric cancer is high, and it is closely related to the carcinoangiogenesis and metastasis.
出处
《世界华人消化杂志》
CAS
2003年第1期33-35,共3页
World Chinese Journal of Digestology
