葛根4’氧代乙酸7羟乙氧基黄豆苷元在大鼠体内的药动学

Pharmacokinetic study on 4' oxo-acetic acid 7 hydroxyethyl daidzein in rats

目的 :制备合成葛根 4’氧代乙酸 7羟乙氧基黄豆苷元 (DZ18) ,研究葛根黄豆苷元衍生物DZ18的体内药动学特征。方法 :采用不同途径给药 :①大鼠颈静脉注射 10 ,2 0 ,3 0mg·kg-1DZ18;②大鼠灌胃给予DZ1880mg·kg-1,③肝门静脉注射 10mg·kg-1DZ18。结果 :大鼠经灌胃、肝门静脉、颈静脉交叉给予DZ18后 ,灌胃的绝对生物利用度为 2 1 95 % ,肝门静脉注射的绝对生物利用度为 82 0 1%。结论 :DZ18ig吸收生物利用度不高 。

AIM: To prepare and study the pharmacokinetic characteristic of 4' oxo acetric acid 7 hydroxyethyl daidzein (DZ18) in rats. METHODS: The rats were administrated the drug crossly by jugular vein injection of 3 doses (10, 20, 30 mg·kg -1 ),intragastric administration (80 mg·kg -1 ) and hepatic portal vein injection (10 mg·kg -1 ). RESULTS: The absolute bioavailability by intragastric administration was 21 95% and hepatic portal vein injection was 82 01%. CONCLUSION: There is no significant elevation in oral administation, DZ18 fits vein injection.