注射用头孢噻肟钠与西咪替丁注射液在4种输液中配伍后的稳定性

Stability after compatibility of cefotaxime sodium and cimetidine in different kinds of intravenous infusions

目的 :考察室温下 6h内注射用头孢噻肟钠与西咪替丁注射液在 4种输液 (5 %GS ,10 %GS ,GNS ,NS)中配伍后的稳定性。方法 :采用一阶导数分光光度法和双波长光谱法测定各配伍液中头孢噻肟钠和西咪替丁的含量。结果 :室温下注射用头孢噻肟钠或西咪替丁注射液单独与 4种输液配伍后 6h保持稳定 ;头孢噻肟钠与西咪替丁注射液配伍后 ,室温下头孢噻肟钠在 4种输液中 6h降解幅度 <2 % ,而西咪替丁 <3 %。结论 :注射用头孢噻肟钠与西咪替丁注射液配伍后在 4种输液中 6h内保持稳定。

AIM: To inspect the stability after compatibility of cefotaxime sodium and cimetidine in 4 kinds of infusions in 6 h in room temperature. METHODS: To test the contents of cefotaxime sodium and cimetidine in all kinds of infusions using first order derivative and double wavelength spectrophotometry. RESULTS: The contents of cefotaxime sodium and cimetidine kept stability in 6 h after they were admixed with 4 kinds of infusions alone.After the compatibility of cefotaxime sodium and cimetidine in 4 kinds of infusions,The contents of cefotaxime sodium degraded less than 2%, and that of cimetidine degraded less than 3%. CONCLUSION: After the compatibility of cefotaxime sodium and cimetidine in 4 kinds of infusions, they kept relatively stability.