丙型肝炎病毒超微结构研究进展被引量：4

Advance on ultrastructural study of hepatitis C virus

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摘要丙型肝炎病毒(HCV)基因组克隆成功后,人们对其基因组的研究已十分深入,但由于HCV病毒颗粒在感染者血中、肝脏中含量很低,血中HCV又往往与免疫复合物和脂蛋白包裹存在,以及缺乏有效的HCV体外培养体系和小动物模型,形态结构研究难度极大而相对滞后,有关HCV超微结构和病毒装配过程还知之甚少,多数研究认为HCV病毒颗粒由外膜及核心组成,外膜表面有钉状突起.HCV感染后的细胞多数可见扩大的胞质囊腔,病毒颗粒多存在胞质囊腔内,这些胞质囊腔认为来自扩大的细胞内质网.细胞核内、胞质、血清、体外培养细胞中HCV颗粒的大小、形式有差异,目前尚无统一认识,其在感染细胞内的形态结构和定位尚不清楚.本文就近年来有关HCV超微结构研究的相关文献进行回顾.

作者程勇前聂青和周永兴

机构地区中国人民解放军第四军医大学唐都医院全军感染病诊疗中心

出处《世界华人消化杂志》 CAS 2003年第2期233-237,共5页 World Chinese Journal of Digestology

基金国家自然科学基金资助课题 No.39970767

关键词丙型肝炎病毒超微结构研究进展

分类号 R373.21 [医药卫生—病原生物学]

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引证文献4

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丙型肝炎病毒超微结构研究进展被引量：4

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