48例肝硬化患者血清类洋地黄物质的测定

Clinical Significance of Measuring Serum Digoxin-Like Substances in Patients with Cirrhosis

用放免法测定了48例肝硬化患者血清类洋地黄物质水平。结果全部患者明显高于对照组。该物质在代偿期已有升高;失代偿期升高更为显著,其程度与腹水量相关。中～大量腹水患者的血清类洋地黄物质水平与血清白蛋白及血钠浓度呈显著负相关。提示血清类洋地黄物质水平的测定可作为估计肝硬化严重程度及预后的一个指标。

The levels of digoxin-like substances were studied by radioimmunoassay in 48 patients with cirrhosis and 30 controls. The mean level of the serum digoxin-like substances in the patients(0.42±0.21ng/ml) was higher than that of the controls (0.02±0.16ng/ml). It was 0.18±0.09ng/ml in the patients with compensative cirrhosis, and much higher in the patients with decompensative cirrhosis, the levels being 0.33±0.04,0.45±0.07 and 0.65±0.13ng/ml in the cases of mild, moderate and large volume of ascites,respectively.While, it was negatively correlated with the levels of serum albumin (P<0.02) and serum sodium (P<0.05) in the patients with moderate or large volume of ascites. The present study showed that the level of serum digoxin-like substances might be an indicator for evaluating the prognosis and situation of the patients with decompensative cirrhosis.