序贯试验法观察奥美拉唑对十二指肠溃疡的近期疗效

The Short-Term Efficacy of Omeprazole in the Treatment of Duodenal Ulcer

本文运用质开放型及量开放型双向序贯试验对比观察了奥美拉唑(Ome)及雷尼替丁(Ran)治疗十三指肠溃疡的近期疗效。结果表明:Ome促进溃疡愈合和缓解疼痛的作用显著优于Ran。本文还对在临床药物评价的研究中运用序贯试验的优越性作了简要讨论。

In this prospective study, sequential trial was designed to compare the shortterm efficacy of omeprazole(Ome) with that of ranitidine (Ran) in patients with duodenal ulcer. We investigated the effects of healing ulcer and relieving pain respectively, after oral administration of Ome (20mg/day) or Ran (300mg/day). After two-week treatment, the healing rate of Ome was 30% or more higher than that of Ran.Relief of ulcer pain of Ome was three days or more faster than that of Ran.We concluded that Ome was much more effective than Ran in promoting cure of ulcer and relief of ulcer pain. In addition, we discussed the advantages of sequential trial which was applied to the research of clinical therapeutic evaluation.