MUC2和E-钙粘附素在胃癌组织中的表达及其意义

The significance of the expression of MUC2 and E-cadherin in gastric carcinomas

目的 :了解粘蛋白 (MUC2 )和E -钙粘附素 (E -cadherin)在原发性胃癌组织中的表达及其与临床病理学行为之间的关系。方法 :应用免疫组化的S -P法检测了 94例原发性的胃癌组织标本中MUC2和E -Cadherin的表达。结果 :MUC2在胃癌组织中的表达的阳性率为 84 % ,不同组织学类型之间MUC2的表达程度有显著性差异 (P <0 .0 5 ) ,尤其在粘液腺癌标本中均呈强阳性表达 (7/7) ;E -cadherin表达的阳性率为 5 6 % (5 3/94 ) ,它的表达与肿瘤的分化有相关趋势 ,但统计学上并无显著性差异 (P >0 .0 5 ) ;MUC2的表达与E -钙粘附素的表达之间有正相关关系 (P <0 .0 5 )。二者的表达与患者年龄、性别、肿瘤的发生部位、有无淋巴结转移、有无胃外器官的转移、肿瘤浸润的深度以及肿瘤的大小均无关 (P >0 .0 5 )。结论 :MUC2是研究不同组织学类型胃癌的较好指标 ,并可作为粘液腺癌的标志物 ;E -钙粘附素的表达与肿瘤的分化有关 ;MUC2的高表达可能可以抑制E -钙粘附素的功能。

Objective:To investigate the significance of the expression of MUC2 gene and E-cadherin in primary gastric cancers. Methods:The proteins were detected by immunohistochemistry. Results: The rate of the MUC2 gene expression was 84% and E-cadherin was 56%.The expression of MUC2 was strongly related to the different types of cancer and had strong expression in all mucinous carcinoma ,but it had no significant difference in patients′ age,gender ,the location of the tumor ,involvement of the lymph nodes,the depth of gastric wall invasion and the metastasis to other organs. As for the expression of E-cadherin,though it had the tendency that it might have the relation with tumor differentiation but significant statistics were not found .There was a positive relationship between the MUC2 and E-cadherin. Conclusion: MUC2 is a good marker for different types of gastric cancers, especially for studying the characteristics of mucinous carcinomas;E-cadherin may influence the differentiation of gastric cancer;MUC2 may have influence on E-cadherin and therefore contribute to the invasion and metastasis of gastric cancers.