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乳腺癌中癌基因抗癌基因表达分析 被引量：5

Analysis of the Expression of Oncogene and Antioncogene in Breast Cancer
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摘要 目的:分析乳腺癌中癌基因、抗癌基因的表达,探讨乳腺癌的发病机制。方法:分别用Cy3和Cy5标记正常乳腺组织和乳腺癌组织的mRNA,与癌基因抗癌基因分类芯片进行杂交,分析两组表达差异。结果:差异表达的基因有39条,其中下调表达的基因有8条,上调表达的基因有31条。结论:说明乳腺癌的发生主要与大量癌基因的过量表达相关。 Objective:Analysis the expression of oncogene and antioncogene in breast can-cer and try to find the pathogenesis of breast cancer.Methods:The mRNA of normal breast tis-sue and breast cancer tissue were labelled by Cy3and Cy5,and hybridized with the classified gene chip of oncogene and antioncogene.Results:There were39genes of differential expression.Among these genes there were8genes of decrease expression and31genes of increase expres-sion.Conclusion:The pathogenesis of breast cancer mainly concerned with the overdos expres-sion of a lot of oncogenes.
作者 牛瑞芳 杨毅 刘红 史玉荣 魏熙胤 孙保存 郝希山
机构地区 天津市肿瘤医院肿瘤研究所基因芯片研究中心
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2003年第3期167-171,共5页 Chinese Journal of Clinical Oncology
基金 天津市科委重大攻关项目基金资助(编号:013182311)
关键词 乳腺癌 癌基因 抗癌基因 基因芯片 Breast cancer Oncogene Antioncogene Gene chip
分类号 R737.9 [医药卫生—肿瘤]
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同被引文献51

  • 1刘德顺,孙强.广泛导管内成分与保乳术后局部复发风险评估[J].癌症进展,2004,2(1):21-25. 被引量：1
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引证文献5

二级引证文献14

中国肿瘤临床
2003年 第3期

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