乳腺癌低氧放疗的远期观察

Long Term Results of Breast Cancer for Hypoxy Radiotherapy

目的:观察低氧对乳腺癌术后放疗皮肤保护作用和对远期疗效的影响。方法:选自1992年3月至1995年3月收治的乳腺癌根治术后患者158例。Ⅱ期91例,Ⅲ期67例。随机分为低氧放疗组85例,常规放疗组73例。应用电子线照射锁骨上、腋窝、胸壁和内乳区。低氧放疗组在放疗开始前吸入10.5%的低氧3～5min直至照射结束。总剂量50～55Gy/25～27次。结果:低氧放疗组照射野内的急性皮肤反应明显较常规放疗组轻,而且出现的晚,但照射野内的后期皮肤改变两组无明显差别。5年生存率分别为92.9%和94.5%,χ2检验无统计学意义。结论:低氧放疗对正常皮肤有明显保护作用,而对生存期无明显影响。

Objective:To assess hypoxia inhalation protective to the skin for breast cancer post-operation radiotherapy and long term results.Methods:From march1992to march1995breast cancer post-operation are treated,among them91cases were in stageⅡ67cases in stageⅢ.The158patents were randomized into2groups85cases entered hypoxyradiotherapy group and73cases the radiotherapy alone group.selected are electronic ray irradiation chest wall su-perclavicular axillary and internal mammary region.Radiotherapy were given5days per week,2Gy per fraction.For hypoxia10.5%oxygen inhalation was started before and lasted2to3min-utes after irradiation.All patients received a total dose50～55Gy.Results:The complete response reaction of the skin appeared late and milder in hypoxy radiotherapy group.The5years survival rates were92.9%and94.5%respectively.Conclusion:Hypoxy radiotherapy may be protective to the normal skin,however lasts radiotherapy reaction and survival rates there is no significant dif-ference in between two groups.