肝移植术后乙型肝炎病毒再感染的防治

Prevention and treatment of hepatitis B re-infection after liver transplantation

目的 探讨肝移植治疗乙型肝炎相关肝病的效果和术后乙型肝炎病毒再感染的防治。方法 观察 17例乙型肝炎相关患者接受肝移植后 ,使用拉米夫定及乙型肝炎免疫球蛋白 (HBIg)的治疗和随访情况。结果 17例肝移植后 ,仅 2例出现HBsAg阳性 ,全部肝功能良好。结论 肝移植是治疗乙型肝炎的有效方法。拉米夫定及HBIg可有效预防肝移植术后乙型肝炎病毒的再感染。

Objective To investigate the effect of liver transplantation on hepatitis B associated diseases and the efficiency of prevention and treatment on the re-infection of hepatitis B.Methods The data of 17 patients undergoing liver transplantation were analyzed after treatment of lamivudine and hepatitis B immune globulin (HBIg). Results Of the 17 cases of hepatitis B pretransplantation, 2 cases were positive for HBsAg. Liver function was normal in all patients.Conclusions Liver transplantation is an effective therapy for hepatitis B. Lamivudine and HBIg could effectively prevent and treat the re-infection of hepatitis B after liver transplantation.