针刺对肥胖大鼠海马组织一氧化氮含量和一氧化氮合酶活性的影响

Effects of acupuncture on contents of nitric oxide and nitric oxide synthase in the hippocampus in the obese rat

目的:探讨针刺对肥胖大鼠海马组织一氧化氮(NO)含量和一氧化氮合酶(NOS)活性的影响。方法:观察针刺治疗前后肥胖大鼠体重、体脂及海马组织NO含量和NOS活性的变化。结果:肥胖大鼠体重、体脂及海马组织NO含量和NOS活性均显著高于正常大鼠水平;大鼠海马组织NO含量和NOS活性与体重和Lee’s指数高度正相关。针刺治疗取得良好减肥疗效。同时,肥胖大鼠海马组织NO含量和NOS活性明显回降。结论:海马组织NO含量和NOS活性异常可能是肥胖发病因素之一;针刺对肥胖机体海马组织NO含量和NOS活性的良性调整作用,可能是实现减肥效应的中枢作用机制之一。

Objective To study effect of acupuncture on the content of nitric oxide (NO) and the activity of nitric oxide synthase (NOS) in the hippocampus of the obese rat. Methods The changes of body weight, body fat, and content of NO and activity of NOS in the hippocampus before and after acupuncture were observed. Results The body weight, body fat, and the content of NO and the activity of NOS in the hippocampus all were significantly higher than those in the normal rat; there were high positive correlation of the levels of NO and activities of NOS in the hippocampus with the body weight, Lee's index; after acupuncture treatment, the marked weight reduction effect was achieved, and the level of NO and the activity of NOS in the hippocampus decreased significantly. Conclusion Abnormal levels of NO and activities of NOS in the hippocampus may be an important factor for obesity; the benign regulation of acupuncture on the level of NO and the activity of NOS in the hippocampus is possibly one of the central nervous mechanisms of reducing body weight.