恶性血液病患者血清Tpo水平与血小板关系的研究

A study on the relationship between serum level Tpo and platelet count in patients with hematological malignancies

目的探讨恶性血液病患者血清Tpo水平与血小板数量的关系及其临床意义。方法夹心酶联免疫法测定 4 0例恶性血液病人血清Tpo水平 ,同时用自动血细胞分析仪测定其血小板数。结果急慢性白血病病人血清Tpo水平均显著高于正常 (P <0 0 1) ,其它恶性血液病的水平低于正常(P <0 0 0 1) ;急性白血病及其它恶性血液病的PLT低于正常 (P <0 0 0 1) ,其Tpo水平与PLT数呈负相关 (r=- 0 .78,r =- 0 .6 2 ,P均 <0 0 0 5 ) ,慢性白血病组Tpo与血小板数不相关 (r=- 0 .2 3,P >0 0 5 )。结论恶性血液病人Tpo与PLT的关系呈异质性。除白血病外 ,其它恶性血液病人当血小板减少时 。

Objective To study the relationship between serum level Tpo and peripheral blood platelet count in patients with hematological malignancies and its clinical value. Methods Tpo level and platelet count were detected in 40 patients with hematological melignant disorders and 18 healthy volunteers by using sandwich ELISA and automatic hemocytoanalyser. Results The Tpo serum level were markedly higher in patients with leukemia and lower in other hematological malignancies than that in controls ( P <0.01 and P <0.001). The platelet number in acute leukemia and other malignant disorders were markedly lower than that in controls ( P <0.001), the platelet number were negative correlate with Tpo level. Conclusion The relationship between platelet and Tpo level in hematological malignancies was hetrogeneity. Treat the thrombocytopenia accompanied with hematological malignancies (except leukemia) with Tpo may be useful.