静脉注射艾司洛尔和毛花苷丙控制快速心房颤动心室率的疗效和安全性比较

COMPARISON OF THE EFFICACY AND SAFETY OF INTRAVENOUS ESMOLOL AND DESLANOSIDE IN DECREASING HEART RATE OF PATIENTS WITH RAPID ATRIAL FIBRILLATION

目的 :观察静脉注射国产艾司洛尔控制快速心房颤动心室率的疗效和安全性。方法 :选择快速心房颤动患者 86例 ,随机分为艾司洛尔组 ( 组 ) 43例、毛花苷丙 (西地兰 )组 ( 组 ) 43例。 组应用国产艾司洛尔采用分级递增静脉注射法 , 组用毛花苷丙 0 .0 0 8mg/kg稀释后 5 min静注 ,1 h无效者重复 1次。观察两组病人用药前后心率、血压、呼吸及临床表现的变化。结果 :1两组有效率分别为 88.4%和 74.4% ( P>0 .0 5 ) ;2心率平均下降为 组 ( 4 3± 1 6)次 /min, 组 ( 2 1± 1 4)次 /min均 P<0 .0 5 ,两组间比较 P>0 .0 5 ;3血压平均下降为 组 ( 8.8± 1 .3) /( 4 .2± 1 .2 ) mm Hg( P<0 .0 5 ) , 组 ( 1 .1± 0 .3) /( 0 .9± 0 .4) mm Hg( P>0 .0 5 ) ,两组间比较 P<0 .0 5 ;4起效时间与最大效应时间 , 组明显快于 组 ;5 组低血压、胸闷各 1例(占 4.6% ) , 组心悸 1例。结论 :国产艾司洛尔临床应用安全、快速。

Objective:To study the efficacy and safety of intravenous esmolol in decreasing heart rate of patients with rapid atrial fibrillation.Methods:86 patients with rapid atrial fibrillation were randomly divided into esmolol group(group Ⅰ,n=43) and deslanoside group (group Ⅱ,n=43).Patients in group Ⅰ were treated by esmolol with gradually increasing intravenous injection and ones in group Ⅱ treated by deslanoside(0 008 mg·kg -1 ·5 min -1 )?Heart rate (HR),blood pressure(BP),respiration and clinical expression were observed.Results:①Effective rate of group Ⅰ was 88 8% and that of group Ⅱ was 74 4%( P >0 05);②The mean declines of HR were (43±16) beats/min(group Ⅰ, P <0 05) and (21±14) beats/min(group Ⅱ, P <0 05)respectively with no difference between two groups( P >0 05);③The mean declines of BP were(8 8±1 3)/(4 2±1 2)mmHg(group Ⅰ, P <0 05)and(1 1±0 3)/(0 9±0 4)mmHg(group Ⅱ, P >0 05)respectively with an obvious difference between two groups ( P <0 05);④The time of therapeutic onset and the time of maximal effect in group Ⅰ were earlier than those in group Ⅱ;⑤One patient having hypotension and one patient with chest distress in group Ⅰ(4 6%).One patient having palpitation in group Ⅱ.Conclusion:Esmolol was safe and highly effective.