雌孕激素联合补充治疗与脑卒中的预防

Estrogen-progestogen replacement therapy and prevention of stroke

目的 探讨低剂量雌孕激素联合补充治疗对脑卒中的预防作用。方法 绝经过渡期及绝经后妇女84例随机设激素补充治疗组和对照组 ,采用酶免法测定治疗前后血脂和雌二醇 (E2 )水平。结果 治疗前后 E2、高密度脂蛋白 (HDL)增高 ,低密度脂蛋白 (L DL)、总胆固醇 (TC)降低 ,差异显著 (P<0 .0 5 ) ,甘油三酯 (TG)变化不明显。结论 低剂量雌激素对血脂谱产生有利影响 。

Objective To study the preventive role of stroke in lower dosage estrogen progestogen replacement therapy. Methods 84 cases in menopausal transition and postmenopausal periods were investigated and were assigned to 2 groups randomly,including hormone replacement therapy group and control group. The level of blood lipid and E2 were measured by enzyme linked immunosorbent assay. Results The level of E2 and HDL were higher,and the level of LDL and TC were lower. A significant difference was noted ( P <0.05). TG was no significant difference. Conclusion The lower dosage estrogen may produce beneficial effect on blood lipids and reduce the development of stroke.