IL和TNF-α与急性下呼吸道感染的关系

Effect of IL and TNF-α levels on patients with acute lower respiratory tract infection

目的 探讨白细胞介素 - 2 (IL - 2 )、白细胞介素 - 6 (IL - 6 )、白细胞介素 - 8(IL - 8)和肿瘤坏死因子 -α(TNF-α)在急性呼吸道感染发病机制中的作用。方法 选择以急性呼吸道感染入院的 30例患者并按临床表现分为重症组和轻症组。采用放射免疫法 (RIA)分别检测急性感染期和痊愈期血清 IL - 2、IL - 6、IL - 8和 TNF-α水平 ,并以 30例健康人血清中 IL - 2、IL - 6、IL - 8和 TNF-α水平作为对照。结果 30例急性呼吸道感染患者血清 IL - 6、IL - 8和 TNF-α水平显著高于健康对照组 (P <0 .0 1) ,并与病情的轻重有关 ;而 IL - 2水平明显低于对照组 (P <0 .0 1) ,但轻症组和重症组间差异无显著性 (P >0 .0 5 )。结论 血清 IL - 2、IL - 6、IL - 8和 TNF-α可能与呼吸道急性感染时的发病机理。

Objective To assess the effect of IL 2?IL 6?IL 8 and TNF α levels in serum on elderly patients with acute lower respiratory tract infection. Methods 30 patients with acute lower respiratory tract infection at different stages and 30 controls was measured the serum levels of IL 2?IL 6?IL 8 and TNF α by RIA. Results The levels of TNF α?IL 6 and IL 8 in 30 patients were obviously increased than that of control group (p< 0.001 ), but the level of IL 2 was lower than that of controls. The increased levels of IL 6?IL 8 and TNF α in serum correlated with clinical parameters. Conclusions The changes of IL 6?IL 8 and TNF α are related to the development in acute inflammation and are markers of severe diseases. They may be considered as useful markers for elderly patients with respiratory tract infection.