冬凌草中的新对映-贝壳杉烷二萜化合物

New ent-Kaurane Diterpenoids from Isodon rubescens

对河南省济源地区产冬凌草 [Isodonrubescens (Hemsl.)Hara]再次进行了深入的研究 ,从其叶的乙酸乙酯提取物中分离得到了 16个化合物 ,其中 1和 2为两个新的 7,2 0 环氧 -对映 -贝壳杉烷类二萜化合物 ,其结构通过波谱分析确定为16(S) 羟甲基 1α ,6β ,7β ,11β 四羟基 7α ,2 0 环氧 -对映 -贝壳杉烷 15 酮 (1)和 16(R) 羟甲基 1α ,6β ,7β ,14 β 四羟基 7α ,2 0 环氧 -对映 -贝壳杉烷 15 酮 (2 ) ,分别命名为冬凌草己素 (1)和庚素 (2 ) ;其余的已知化合物分别鉴定为lasiodonin (3) ,冬凌草甲素 (oridonin ,4) ,乙素 (ponicidin) ,丙素 (rubescensinC) ,丁素 (rubescensinD) ,牛尾草丙素 (rabdoterninC) ,荛花香茶菜乙素 (wikstroemioidinB) ,enmenol 1α O β D glucoside ,enmenol,胡麻素 (pedalitin) ,水杨酸 ,乌索酸 ,β

Two new ent-kaurane diterpenoids, 16( S)-hydroxymethyl-1alpha, 6beta, 7beta, 11beta-tetrahydnoxy-7a, 20-epoxyent-kauran-15-one (1) and 16 ( R)-hydroxymethyl-1alpha, 6beta, 7beta, 14beta-tetrahydroxy-7alpha, 20-epoxy-ent-kauran-15-one (2), named rubescensins F (1) and G (2), respectively, were isolated from the EtOAc extract of the dried leaves of Isodon rubescens ( Hemsl.) Ham collected in Jiyuan Prefecture, Henan Province, together with fourteen known compounds lasiodonin (3), oridonin (4), ponicidin, rubescensins C and D, rabdoternin C, wikstroemioidin B, enmenol-1alpha-O-beta-D-glucoside, enmenol, pedalitin, salicylic acid, ursolic acid, beta-sitosterol and daucosterol. Their structures were determined on the basis of spectral data.