睑板腺癌临床组织病理学特点及影响预后因素

Clinical and histopathologyc features in sebaceous gland carcinoma and analysis of prognostic predictors

目的 通过系统分析睑板腺癌的临床及组织病理学特点 ,探讨影响睑板腺癌的临床预后因素。方法 选取北京同仁医院眼科存档睑板腺癌病例 5 5例。对患者进行临床随诊、随访 ;依据原始记录和随访反馈情况 ,对临床及组织病理学各项因素逐项进行统计 ( L ogistic回归分析 ) ,并进行综合分析评价。结果 睑板腺癌患者年龄 33～ 90岁 ,5 0～ 70岁较多 ,平均发病年龄 6 3岁。女性略多于男性。发病部位以上睑为多 ,位于上睑的睑板腺癌占 6 9.0 9% ,位于下睑者占2 7.2 7% .结论 睑板腺癌临床预后系多因素多变量结果 ,与患者年龄、病程长短密切相关 ,亦与肿瘤大小、肿瘤侵犯的解剖位置以及肿瘤分化程度等多种因素有一定关联。

ObjectiveTo analyze the clinical and histopathologic features and the factors to affect prognosis of the sebaceous gland carcinoma.MethodsFifty-five cases of the sebaceous gland carcinoma were retrieved from the ophthalmology archives at Tongren Hospital. All patients were followed-up. According to the initial recording and follow-up feedback, every clinical and histopathologic factors were analyzed statistically(Logistic regression analysis) and evaluated overall.ResultsThe ages at presentation distribute in 33~90 years old, most in 50~70 years old, and the mean age at presentation was 63 years old. The incidence for females was a little higher than that for males. The tumors were primarily located in the superior eyelid whose rate was 69.09%, while the rate of those located in the inferior eyelid was 27.27%.ConclusionThe outcome of the sebaceous gland carcinoma is a result of multi-factors, which is related not only closely to the age of the suffer and the length of the disease course, but also to the tumor size, the site of the tumor invading and the extend of tumor differentiating in some extend.