血管性痴呆大鼠尾状核血脑屏障的超微结构

Ultrastructure of Caudatolenticular Blood-brain Barrier in Vascular Dementic Rats

目的 观察血管性痴呆大鼠尾状核血脑屏障结构特点 ,探讨血管性痴呆发病机制。 方法 采用结扎双侧颈总动脉的方法建立痴呆动物模型 (假手术对照组和痴呆组各 5只 ) ,以 Morris水迷宫和 Y型电迷宫检验大鼠学习能力 ,应用透射电镜观察尾状核血脑屏障的特点。 结果 痴呆组尾状核毛细血管内皮细胞局部基膜增厚 ,轮廓不清 ,并形成一些致密度不均匀的物质。基膜外突起肿胀 ,内容物减少甚至消失 ,基膜外见髓样物 ,其毛细血管内皮细胞细胞质线粒体数量减少 ,大部分线粒体嵴模糊、断裂甚至消失。 结论 血管性痴呆大鼠由于尾状核内皮细胞基膜受损 ,星形胶质细胞终足突起改变 ,使血脑屏障通透性增加 。

Objective\ To study the relationship between the pathogenesis of vascular dementia(VD) and the ultrastructural character of blood\|brain barrier(BBB) in the caudatolenticulum.\ Methods\ The ultrastructure of BBB in caudatolenticulum of 10 rats of which 5 rats bilateral common carotid arteries were occluded and 5 rats as control group.\ Results\ The outline of some basement membranes of capillaries in VD rats was unclear, thicker and has uneven density.\ There were myelinic materals outside some basement membrances.\ Some astrocyte protrusions swell and their contents lessen.\ \{Conclusion\}\ Increasing the permeability of BBB makes odema and neurons damaged, and induce VD.\ That capillary basement membranes and protrusion of astrocyte are destroyed.\;