结直肠癌和同时性肝转移灶转化生长因子β_1的表达

Expression of Transforming Growth Factor β_1 in Colorectal Carcinoma and Synchronous Metastatic Liver Tumor

目的 研究结直肠癌和其同时性肝转移灶中转化生长因子β1 (TGF-β1 )的表达与微血管密度、预后的关系。 方法 应用免疫组织化学 SP法检测 TGF-β1 和 CD34 在 30例结直肠癌和其同时性肝转移灶中的表达 ,分析肝转移灶中 TGF-β1 的表达与预后的关系。 结果 结直肠癌原发灶中 TGF-β1 的阳性表达率、微血管密度均高于其同时性肝转移灶 (P<0 .0 1) ;原发灶和肝转移灶中 TGF-β1 阳性表达组的微血管密度分别高于相应的 TGF-β1 阴性组 (P<0 .0 5 ) ;经 Gehan比分检验 ,结直肠癌肝转移灶中 TGF-β1 的表达同手术切除后患者的预后呈负相关 (P<0 .0 5 )。 结论 TGF-β1 在结直肠癌和其同时性肝转移灶的肿瘤血管生成中起重要作用 ,肝转移灶中 TGF-β1

Objective\ To investigate the relationship between the expression of transforming growth factor\|β\-1(TGF\|β\-1) and the intratumoral microvessel density(MVD), and the prognosis of human colorectal carcinoma and their synchronous metastatic liver tumor.\ Methods\ The SP immunohistochemical stain method was used to observe the expression of TGF\|β\-1 and CD\-\{34\} in 30 specimens of colorectal carcinoma and liver metastatic tumor.\ The relationship was investigated between the expression of TGF\|β\-1 in the metastatic liver carcinoma and prognosis.\ Results\ The positive rate of TGF\|β\-1 and the value of MVD in colorectal primary tumor were higher than those in their synchronous liver metastatic tumor, P<0 01.\ The value of MVD in colorectal primary and liver metastatic carcinoma which had positive TGF\|β\-1 expression were higher than those negative TGF\|β\-1 expression, P<0 05.\ TGF\|β\-1 expression of liver metastatic tumor was negative correlation with the prognosis, P<0 05.\ Conclusion\ TGF\|β\-1 played an important role in the neoplastic angiogenesis of colorectal carcinoma and their liver matestatic tumor.\ Expression of TGF\|β\-1 in liver metastatic tumor is associated with poor prognosis.\;