肝细胞癌尿激酶型纤溶酶原激活物及其受体的表达

Expression of Urokinase-type Plasminogen Activator and its Receptor in Hepatocellular Carcinoma

目的 研究尿激酶型纤溶酶原激活物 (u PA)及其受体 (u PAR)与肝细胞癌 (HCC)的关系以及在 HCC侵袭转移中的作用。 方法 应用原位杂交方法分别检测 5 2例 HCC、4 2例肝硬化组织和 2 3例正常肝组织中u PA、u PAR m RNA的表达。 结果 HCC组 u PA、u PAR m RNA的阳性表达分别为 31/ 5 2 ,34/ 5 2 ,明显高于肝硬化组及正常肝组织组 (P<0 .0 5 )。 HCC组包膜侵犯者 u PA、u PAR m RNA的阳性表达分别为 2 5 / 34,2 8/ 34,与无侵犯者 (6 / 18,6 / 18)相比 ,P<0 .0 1;转移组 u PA、u PAR m RNA的阳性表达分别为 2 1/ 2 6 ,2 3/ 2 6 ,与无转移者 (10 / 2 6 ,11/ 2 6 )相比 ,P<0 .0 1。 结论 u PA、u PAR m RNA在 HCC中的表达明显升高 ,u PA、u

Objective\ To study the relationship between urokinase\|type plasmingen activator(uPA), uPA receptor(uPAR) and tumor cell invasion,metastasis in hepatocellular carcinoma(HCC).\ Methods\ The expression of uPA, uPAR mRNA was detected in 52 cases of HCC, 42 cases of liver cirrhosis and 23 cases of normal liver tissue by in situs hybridization.\ Results\ In HCC cell, the expression of uPA and uPAR mRNA were 31/52 and 34/52, which were significantly higher than liver cirrhosis and normal liver tissue(P<0.05).\ Compared by 6/18 in HCC with integral capsule, the expression of uPA and uPAR mRNA in capsule invaded HCC were 25/34 and 28/34 respectively(P<0.01); the metastative cases were 21/26 and 23/26, respectively(P<0.01).\ Conclusion\ Expression of uPA, uPAR mRNA is increased in HCC, and uPA and uPAR may contribute significantly to HCC invasion and metastasis.\;