桂苓散的抗癌作用

The Antitumor Activity of Herb Gui-Lin-San

目的 探讨桂苓散的体内抗肿瘤活性及其与化疗药物的协同作用。 方法 用小鼠肝癌腹水型 H2 2 、艾氏腹水瘤 EAC模型 ,观察药物对小鼠腹水生成量的影响 ;用小鼠宫颈癌 U1 4模型 ,观察药物对小鼠瘤块生成的影响 ;同时观察药物与五氟脲嘧啶 (5 - FU )、环磷酰胺 (CTX)联合应用对抗肿瘤活性的协同作用。 结果 桂苓散对腹水瘤能抑制腹水的生成 ,对实体瘤也有抑制作用。与 5 - FU(2 5 mg· kg- 1· d- 1× 1,ig)合用能显著提高 5 - FU对腹水瘤小鼠的腹水生成的抑制作用。与轻度抑瘤作用剂量的 CTX(2 5 m g· kg- 1 · d- 1 × 1,ig)合用 ,对实体瘤抑瘤活性高于单独给药组。 结论 桂苓散具有一定的抗肿瘤作用并对 5 - FU。

Objective\ To study the antitumor activity of the chinese herb Gui\|Lin\|San(GLS).\ Methods\ The influences of the GLS in ascitic fluid quantity in mice inoculated with hepatic ascites carcinoma cells(H\-\{22\}) and Ehrlich ascites carcinoma(EAC) were determined.\ The influences of the GLS in oncogenesis in mice inoculated with solid tumor U\-\{14\} also its synergetic effects to commonly\|used chemotherapeutic agents such as 5\|fluorouracil(5\|FU) or cytoxan(CTX) was determined.\ Results\ The GLS had effect against the ascitic tumors and inhibition on the growth of the solid tumors respectively.\ Combined with low dose of 5\|FU(25 mg·kg\+\{-1\}·d\+\{-1\}×1, ig), the GLS can greatly inhibited fluid formation of mice with ascitic tumors.\ In combination slight tumor\|inhibitory dose of CTX(25 mg·kg\+\{-1\}·d\+\{-1\}×1, ig) with GLS, the effect was much pronounced than that of single CTX.\ Conclusion\ The GLS have anti\|tumors effect and the antitumor effect was significantly promoted by combining GLS with 5\|FU or CTX.\;