外伤性增生性玻璃体视网膜病变的电镜观察

Ultrastructural and electron study of traumatic proliferative vitreoretinopathy(tPVR) membrane

目的 探讨外伤性增生性玻璃体视网膜病变 (traumaticproliferativevitreoretinopathy ,tPVR)细胞增生的特征。方法 对 10例tPVR的玻璃体切除标本进行了透射电镜观察。结果 tPVR的增生特征以成纤维细胞及胶原纤维为主。 3例标本可见吞噬细胞及色素颗粒 ,4例标本可见少数视网膜色素上皮 (RPE)细胞 ,3例可见血管组织。结论 tPVR以纤维增生为主 ;玻璃体出血可引起以巨噬细胞为主的炎症反应 ,刺激增生 ;有血管参与tPVR的增生过程。

Objective To evaluate the characteristics of cellular proliferation in 10 specimens of traumatic prolifertive vitroretinopathy (tPVR) from 10 tPVR patients. Methods 10 specimens of tPVR membranes obtained from vitrectomy were investigated for ultrastructure by transmission electron microscopy. Results Fibroblasts and collagen fibers are the phenotypes seen in tPVR membranes.There is a small population of macrophages in 3 specimens,RPE cells in 4 specimens and vascular component in 3 specimens. Conclusion In tPVR membranes,most of the proliferative cells were derived from fibroblasts and the mainly extracellular matrix is collagen fibers.Vitreous hemorrhage play an important role in initiating chronic inflammatory reaction patricipated mainly by macrophages and accelerating the development of tPVR.A neovascular process in tPVR should be considered.