微核试验在中国的应用、发展与展望

The Applications,Developments and Expectations of Micronucleus Test in China

微核试验是反映染色体损伤的重要试验方法,已广泛应用于遗传、食品、药物、环境等多领域的遗传毒性评估,以及作为有害职业和生活环境暴露人群遗传损害的生物标志物。我国开展微核试验已有二十余年的历史,本文通过检索《中国生物医学文献数据库》(1980～2000),共检索到有关微核的专题研究文献共1316篇,研究内容涉及微核的文献共2083篇。本文对微核的相关信息进行了分析,并结合作者自己的研究工作,回顾了微核试验在中国的应用和发展,总结了我国学者开展该项工作的优势与不足,对微核试验在我国的进一步发展进行了展望。

The micronucleus test(MNT) is an important method to reflect chromosomal damage,it is already widely used in genetic toxicity evaluations of genetics,foods,drugs and environment,and also used as biomarker of genetic damages for populations who exposured to baleful occupational and living environments.The MNT was used in China nearly about twenty years,there are 1316 references which title contained micronuclei and 2083 which contents related to micronuclei found after checking 'China Biological and Medical Disc(CD disk/network 1980～2000)'.The author analysed the related informations about micronuclei,reviewed the applications and developments of MNT in China,summarized the advantages and disadvantages of Chinese scientists's research works,and made a expectations of future developments of MNT in China combined with his own research works.