富含半胱氨酸病毒蛋白的研究进展

Recent Advances in the Studies of Viral Encoded Small Cysteine Rich Proteins

病毒编码的富含半胱氨酸的小分子量蛋白 (CRPs)在植物和动物病毒中均有发现。动物病毒中研究较多的是反转录病毒的核蛋白 (NC)。在植物病毒中由hordei ,tobra ,furo andcarlaviruses编码的CRPs的分子生物学研究近年来才开展起来。动物和植物病毒的CRPs共有的典型特征是均有锌指结构和碱性氨基酸丰富区 ,这使它们在核酸结合特性上有共同特征。动物病毒CRPs的结构和功能方面的研究已有很好的进展。相反 ,植物病毒的CRPs的研究进展较为缓慢。本文对病毒的CRPs的最新进展进行了综述。对动物和植物病毒的CRPs的比较分析有助于将来这类蛋白功能的阐明。

Small cysteine rich proteins (CRPs) are commonly encoded by the genomes of both animal and plant viruses.The best studied CRP in animal viruses is the NC protein of several retroviruses.In plant viruses,the molecular biology of CRPs specified by members of hordei-,tobra-,furo- and carlaviruses are just begun to be analyzed in recent years.The most important common feature among CRPs of animal and plant viruses is the possession of zinc finger structure and structural motif rich in basic amino acid residues in their proteins.This leads to a shared nucleic acid binding property among the CRPs.Much advance has been made in understanding the structure and function of animal viral CRPs.In contrast,the progress in investigations of plant viral CRPs has been relatively slow.In this paper,the latest knowledge on viral CRPs is reviewed.It is concluded that comparative analysis of animal and plant viral CRPs will facilitate functional dissection of this type of proteins in the future. ;