期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

不对称二甲基精氨酸与心血管疾病 被引量：3

下载PDF
导出
摘要 不对称二甲基精氨酸 (ADMA)是一种内源性、由N 甲基转移酶催化产生的L 精氨酸类似物 ,也是一种NOS抑制剂。研究表明ADMA合成、代谢失常 ,体内蓄积是肾衰末期、动脉粥样硬化、高胆固醇血症、高甘油三酯血症、高血压和心衰等疾病时内皮功能失常的原因。血浆ADMA升高可能是心血管疾病的标志物或危险因子之一。
作者 孙纪新
机构地区 河北省医学科学院
出处 《实用心脑肺血管病杂志》 2003年第1期62-62,F004,共2页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词 不对称二甲基精氨酸 一氧化氮 一氧化氮合酶 心血管疾病
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献20

  • 1[1]Moncada S,Higgs EA.The L-arginine-nitric oxide pathway.N Engl J Med.1993,329;2002～2012.
  • 2[2]Vallance P,Leone AM,Calver A,et al.Accumulation of an endogenous inhibitor of NO synthesis in chronic renal failure.Lancet.1992,339:572～575.
  • 3[3]Boger RH,Bode-Boger SM.Asymmetric dimethylarginine,derangements of the endothelial nitric oxide synthase pathway,and cardiovascular diseases.Sem Thromb Hemost.2000,26:539～545.
  • 4[4]Fickling SA,Leone AM,Nussey SS,et al.Synthesis of N,N-dimethylarginine by human endothelial cells.Endothelium.1993,1:137～140.
  • 5[5]Leiper J,Vallance P.Biological siginificance of endogenous methylarginines that inhibit nitric oxide synthases.Cardiovasc Res.1999,15(43):542～548.
  • 6[6]Boger RH,Sydow K,Borlak J,et al.LDL cholesterol upregulates synthesis of asymmetrical dimehylarginine in human endothelial cells:involvement of S-adenosylmethionine-dependent methyltransferases.Circ Res.2000,87:99～105.
  • 7[7]Ito A,Tsao PS,Adimoolam S,et al.Novel mechanism for endothelial dysfunction:dysregulation of dimethylarginine dimethylaminohydrolase.Circulation.1999,99:3097～3095.
  • 8[8]Vallance P.The asymmetrical dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in the regulalation of nitric oxide generation.Clin Sci (Colch).2001,100:159～160.
  • 9[9]Boger RH,Bode-Boger SM,Szuha A,et al.Asymmetric dimethylarginine:A novel rask factor for endothelial dysfunction and its role in hypercholesterolemia.Circulation.1998,98:1842～1847.
  • 10[10]Wolf A,Zalpoor C,Theilmeier G,et al.Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans.J Am Call Cardiol.1997,29:479～483.

同被引文献30

  • 1姚瑞,党瑜华,张菲斐.非对称性二甲基精氨酸与血管内皮功能[J].心血管病学进展,2005,26(2):175-177. 被引量：4
  • 2Boger RH, Bode - Boger SM, Szuba A, et al. Asymmetric Dimethylarginine(ADMA) :a novel risk factor for endothelial dysfunction:its role in hypercholesterolemia[J]. Circulation,1998,98: 1842- 1847.
  • 3Boger RH, Boger SM, Tsao PS, et al. An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesivenesis for monocytes [ J ] . J Am Coll Cardiol, 2000, 36 :2287 - 2295.
  • 4Boger RH, et al. Supplementation of hypercholesterolaemic rabbits with L- arginine reduces the vascular release of superoxide anions and restores NO production[J]. Atherosclerosis, 1995,117:273 - 284.
  • 5王世阆.妊娠高血压综合征[A].乐杰 主编.妇产科学:第5版[C].北京:人民卫生出版社,2000.114-122.
  • 6Raij L. Role of the angiotensinⅡ-nitric oxide interaction[J]. Hypertension, 2001;37:767-73.
  • 7Bragulat E, de la Sierra A, Antonio MT, et al . Endothelial dysfunction in salt-sensitive essential hypertension[J]. Hypertension,2001;37( Part 2): 444-8.
  • 8Dzau V. Tissue angiotensin and pathobiology of vascular disease. A unifying hypothesis[J]. Hypertension, 2001;37:1047-52.
  • 9Hodge G, Ye VZ, Duggan KA. Salt-sensitive hypertension resulting from nitric oxide synthase inhibition is associated with loss of regulation of angiotensin II in the rat[J]. Exp Physiol, 2002;87:1-8.
  • 10Tan DY, Meng S,Cason GW, et al . Mechanisms of salt-sensitive hypertension: role of inducible nitric oxide synthase[J]. Am J Physiol Regul Integr Comp Physiol, 2000;279: R2297-303.

引证文献3

二级引证文献2

实用心脑肺血管病杂志
2003年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部