地方性氟中毒病区更年期妇女绝经年龄及其影响因素的调查分析

Investigation of women's menopause status and its affective factor in endemic fluorosis area

目的:探讨地方性氟中毒病区氟对更年期妇女的绝经年龄的影响及其影响因素。方法 :采用环境卫生学调查方法对新疆奎屯垦区 2 5 36名 38～ 6 0岁妇女进行了调查研究。结果:氟对更年期妇女绝经年龄的影响呈现双峰趋势 ,提示氟对妇女的生殖内分泌功能的作用为双重的剂量反应效应。与对照组 (水氟浓度≤ 1mg/ L )相比 ,高氟组妇女绝经年龄延迟 (P <0 .0 5 ) ,痛经曾患率低 (RR=0 .82 ,95 % ,CI:0 .6 8～ 0 .98)。其中低度高氟组 (水氟浓度 1～ 3mg/ L)绝经概率变化速率快于对照组 (P <0 .0 5 )。随着在高氟区居住年限的延长 ,妇女绝经年龄后移更为明显 (P <0 .0 5 )。 结论 :适量的氟 (水氟浓度≤ 1m g/ L)有利于机体健康 ,而高氟可使高氟区妇女更年期延迟 。

Abastract: Objective: To study women's menopause status and its affective factor in endemic fluorosis area. Methods: By environmental epidemic survey. Results: Certain fluoride content in drinking water can meet a later menopause age and the living longer the later of menopause age in endemic fluorosis area. The distribution of menopause age in 38~60 women showed two kurtosis in this area. The prevalence rate of dysmenorrhea was lower than control group (relative risk (RR)=0.82, 95% confidence interval: 0.68 to 0.98 ). The menopause age was not significant between smoking group (P>0.05). Menstruation disorder rate was higher in fluoride group (P<0.05). Conclusion: Certaion fluoride in drinking water may connect with a getting menopause age later and reduce some disease rate in endemic fluorosis area. As having been reduced fluoride in water, women's genital toxicity and fecundity can be changed.