爱迪注射液配合化疗治疗老年恶性肿瘤疗效观察

Observation on Efficacy of Aidi Injection Combined with Chemotherapy in Treating Malignant Tumor in Aged Patients

目的 :比较爱迪注射液加化疗 (治疗组 )与单纯化疗 (对照组 )对老年恶性肿瘤的疗效、毒副反应及免疫功能的影响。方法 :治疗组 :化疗同时加用爱迪注射液 5 0ml溶于生理盐水 5 0 0ml中 ,每天 1次 ,连用 4周。对照组单用化疗。结果 :有效率治疗组 4 4 4 % ,对照组 33 3% ,两组比较差异无显著性 (P >0 0 5 )。治疗组病变进展率、血液毒副反应、胃肠道反应、治疗前后免疫功能改变均明显低于对照组 ,差异有显著性 (P<0 0 5 )。生活质量评分治疗组高于对照组 ,两组间差异有显著性 (P <0 0 5 )。结论 :爱迪注射液与化疗联用治疗老年恶性肿瘤 ,可降低了化疗对患者免疫功能的影响及毒副反应 ,改善患者的生活质量。

Objective: To compare the therapeutic effect, adverse reaction and effect on immunity of chemotherapy combined Aidi Injection (AI)with those of chemotherapy alone in treating malignant tumor of aged patients. Methods: To the treated group, in the same time of applying chemotherapy, 50 ml of AI was given intravenously by dissolving in 500 ml of normal saline per day for 4 successive weeks, while to the control group, only chemotherapy was given. Results: The effective rate in the treated group and the control group was 44.4% and 33.3% respectively, with insignificant difference between the two groups (P>0 05). But the rate of progression, adverse reaction in blood, digestive tract and change of immunity in the treated group were all lower than those in the control group with significance (P<0 05), and the improvement in Karnofsky scores in the former was higher than that in the latter (P<0 05). Conclusion: Chemotherapy supplemented with AI shows apparent effect in treating malignant tumor in aged patients, it could lower the influence on immunity and adverse reaction of chemotherapy, and improve the quality of life of patients.