非酶糖基化与血管老化的关系

The Relationship Between Nonenzymatic Glycosylation and Vascular Aging

以非酶糖基化衰老学说为依据,系统回顾了生理及病理状态下,非酶糖基化反应作用于血管,造成血管损伤的相关文献,证实了随着增龄,机体的非酶糖基化程度逐渐加深,并可通过多种途径作用于血管,引起血管与老化相关的一系列形态与功能的改变。文章试通过对非酶糖基化与血管衰老二者关系的初步探讨,为今后延缓血管老化的研究提供相应的理论依据。

Based on the theory of aging: nonenzymatic glycosylation,we review the articles about how the reaction of nonenzymatic glycosylation makes effect on blood vessels,causing vascular injury both under physiological and pathological conditions. These works confirm that the process of nonenzymatic glycosylation becomes more serious with increase of age,which can damage blood vessels through many complicated ways and lead to vascular age-related changes in range of form and function. This article tries to discuss the relationship between nonenzymatic glycosylation and vascular aging,aiming to provide the theoretical basis for future research of delaying vascular aging.