MicroRNA在胆固醇逆转运中的调节作用

Role of MicroRNA in Reverse Cholesterol Transport

胆固醇逆转运是体内清除胆固醇的唯一机制,对维持体内胆固醇稳态有重要意义。MicroRNA与体内诸多病理生理过程关系密切,如肿瘤、脂质代谢、免疫功能等,并逐渐成为新的药物靶点。最近发现MicroRNA对胆固醇逆转运有调节作用。本文综述了可调节胆固醇逆转运的MicroRNA,主要包括miR-33、miR-758、miR-106b、miR-26、miR-27。这些研究结果表明,MicroRNA对胆固醇逆转运及动脉粥样硬化有重要意义,为临床防止动脉粥样硬化提供新的药物靶点。

Reverse cholesterol transport( RCT) is the only mechanism of cholesterol efflux in the body. It is important to maintain the cholesterol homeostasis. MicroRNAs have a close relationship with many pathophy-siological processes in vivo,such as tumor,lipid metabolism and immune function. MicroRNAs gradually become new drug targets. The recent studies indicate that MicroRNAs play important roles in RCT. This paper reviews the MicroRNAs that can regulate the RCT process,including miR-33,miR-758,miR-106b,miR-26,miR-27. These findings show that MicroRNAs play important roles in RCT and atherosclerosis,and provide new drug targets for clinical prevention Atherosclerosis.