不对称二甲基精氨酸与脑梗死发病的关系

The Study of Correlation Between Plasma Asymmetric Dimethylarginine and Cerebral Infarction

目的检测脑梗死患者血浆中不对称二甲基精氨酸(ADMA)含量,分析ADMA与脑梗死、ADMA与脑梗死其他传统危险因素之间的关系,探讨ADMA在脑梗死发病中的作用。方法选取100例脑梗死患者(脑梗死组),以80例健康体检者为对照组。采用高效液相色谱法测定两组研究对象血浆中ADMA含量,同时测量空腹血糖、血脂及平静状态血压。对脑梗死的各危险因素做Logistic回归分析和Spearman相关分析。结果 (1)脑梗死组血浆ADMA水平较对照组显著升高,差异有统计学意义(1.48±0.60 mg/L比0.91±0.47 mg/L,P<0.01)。(2)Logistic回归分析结果表明,收缩压、低密度脂蛋白、吸烟、ADMA、脑动脉狭窄或闭塞为脑梗死的独立危险因素。(3)Spearman相关分析发现,ADMA与收缩压、低密度脂蛋白、肌酐、吸烟、脑动脉狭窄或闭塞呈正相关。结论高ADMA血症与脑梗死发病关系密切。ADMA可作为脑梗死危险因素的一个检测指标。

Aim To detect the plasma levels of asymmetric dimethylarginine( ADMA) in patients with cerebral infarction( CI); To analyze the relations between ADMA and CI,other traditional risk factors of CI; To explore the role of ADMA in the pathogenesis of CI. Methods 100 patients with CI were collected( CI group),and 80 healthy examination individuals were as the control group. Plasma level of ADMA was determined by high performance liquid chromatography in the two groups. Fasting blood glucose,lipids and blood pressure in a calm state were measured at the same time.Logistic regression analysis and Spearman correlation analysis were performed on the risk factors of CI. Results( 1)Compared with control group,the level of plasma ADMA in CI group was obviously increased( 1. 48 ± 0. 60 mg / L vs 0. 91± 0. 47 mg / L,P < 0. 01).( 2) Logistic regression analysis showed that systolic blood pressure,low density lipoprotein,smoking,ADMA,and cerebral artery stenosis or occlusion were independent risk factors for CI.( 3) Spearman correlation analysis showed that ADMA was positively correlated with systolic blood pressure,low density lipoprotein,serum creatinine,smoking,and cerebral artery stenosis or occlusion. Conclusions High plasma level of ADMA is closely related with the occurrence of CI. ADMA can be used as a detection index of the CI risk factors.