摘要
凝集素样氧化型低密度脂蛋白受体1(LOX-1)是血管内皮细胞上氧化型低密度脂蛋白的主要受体,其胞外结构域被降解后释放到血液中,形成可溶性LOX-1(s LOX-1)。血清s LOX-1水平在动脉硬化及血管内皮细胞损伤相关疾病患者中明显升高,是极具研究潜力的生物标志物。本文首次对s LOX-1作为心血管等疾病生物标志物的最新研究进展进行了全面综述。
The lectin-like oxidized low density lipoprotein receptor-1( LOX-1) on the vascular endothelial cell is the main receptor for oxidized low density lipoprotein. The extracellular domain of LOX-1 on the cell surface can undergo proteolysis and be released as soluble LOX-1( s LOX-1). The level of s LOX-1 in serum elevates for relative disease with atherosclerosis and vascular endothelium injuries,which suggests s LOX-1 is a promising biomarker. In the present paper the cardiovascular related diseases regarding s LOX-1 as biomarker were firstly reviewed in detail.
出处
《中国动脉硬化杂志》
CAS
北大核心
2015年第10期1061-1065,共5页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金(81072564)
吉林省科学技术厅科技发展计划(20130727036YY和20140203001YY)
